įor some conditions like drug and food allergies or infections, treatment can be simple, like withdrawing the offending agent or treating with antibiotics. In emergency conditions with hemodynamic instability or organ failure, treatment with IV steroids is important. In mild cases without any symptoms or signs of organ involvement, a conservative approach can be undertaken. The goal of the therapy is to mitigate end-organ damage from eosinophilia. Management depends on the underlying cause. Stool testing helps to assess for parasitic infections. Ultrasound abdomen helps to evaluate for splenomegaly. Imaging of the chest helps diagnose aspergillosis, Loeffler syndrome, Churg Strauss syndrome.
#Caprine meaning skin#
When skin rashes are present, skin biopsy helps to diagnose cutaneous disorders like pemphigoid, eczema, mycosis fungoides, Sezary syndrome. ī12 level and tryptase level, along with cytogenetic/immunophenotypic testing and marrow findings, help diagnose chronic mastocytosis, acute/chronic myeloid leukemia, myelodysplastic syndrome, MDS/MPN overlap. In that case, bone marrow biopsy, along with karyotype and genetic screen of chromosomes, may be required. Ĭoncurrent cytophilias or cytopenias, if present, can help for diagnosis. Cytogenetic testing and FISH analysis can be performed on peripheral blood as well. Diagnostic testing should start with peripheral smear. The evaluation for primary eosinophilia should begin with screening peripheral blood for FIP1L1- PDGFRA gene fusion. Secondary causes of eosinophilia should be ruled out first. Physical examination should be complete, including a skin assessment, lung auscultation to look for rhonchi, wheezes, abdomen exam to look for splenomegaly. Detailed travel history, work environment, drug history, close contacts with HIV, syphilis helps identify infections, parasitic infestations, and drug adverse reactions. Dyspnea, cough, wheezing can be seen in multiple conditions, including bronchopulmonary aspergillosis, Loeffler's syndrome, hay fever, asthma, reactive pulmonary eosinophilia, Churg strass syndrome. Skin rashes, pruritus can be seen in cutaneous T cell lymphoma, eczema.
Constitutional symptoms like low-grade fevers, night sweats, fatigue, weight loss can occur in multiple conditions, including myeloproliferative and lymphoid neoplasms, Churg Strauss syndrome, DRESS syndrome. Skin, pulmonary, and gastrointestinal organ systems are commonly involved. Due to the heterogeneous manifestations of the disease and severity varying from mild to end-organ damage, comprehensive history taking and diligent physical examination is extremely important, and sometimes enough, for diagnosis.
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